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Tetrakis-Hydroxymethyl Phosphonium Chloride

Tetrakis - Tetrakis-Hydroxymethyl Phosphonium Chloride, commonly known as THPC, is an organophosphorus compound with diverse applications. Besides the applications, properties, and hazards introduced before, here are some additional details:


  • Synthesis

  • : THPC can be synthesized with high yield by treating phosphine with formaldehyde in the presence of hydrochloric acid.

  • Applications in Different Industries

    • Textile Industry

  • : In the production of crease - resistant and flame - retardant finishes on cotton textiles and other cellulosic fabrics, THPC is of great significance. For example, in the Proban process, THPC is treated with urea. The urea condenses with the hydroxymethyl groups on THPC, and the phosphonium structure is converted to phosphine oxide. The resulting product is applied to fabrics through a "pad - dry process," and then the treated material is treated with ammonia and ammonium hydroxide to make the fibers flame - retardant.

  • Water Treatment

  •  THPC can effectively bind and remove heavy metals and other contaminants from aqueous solutions due to its chelating properties. It is used in industrial and commercial recirculating cooling water systems, heat transfer water systems, and industrial process water systems to control bacteria, algae, and fungi.

  • Leather Industry: It is used as a tanning agent, which can improve the quality and durability of leather.

  • Catalysis Field: It can be used as a phase - transfer catalyst and a polymerization catalyst, playing a role in promoting chemical reactions


  • Material Science: It is used to modify the properties of various materials. For example, it is used as a cross - linking agent in the preparation of protein - based hydrogels for 3D cell encapsulation, which can control the gelation time and mechanical properties

  • Chemical Reaction Characteristics

  • THPC can condense with many other types of monomers in addition to urea, such as amines, phenols, and polybasic acids and anhydrides. The hydroxymethyl groups on THPC can also undergo replacement reactions. For example, when THPC is treated with α,β - unsaturated nitrile, acid, amide, and epoxides, the base can induce the condensation between THPC and acrylamide with the displacement of the hydroxymethyl groups.

  • Environmental Impact: THPC is toxic to aquatic organisms. It may have potential impacts on the ecological environment. Therefore, it is necessary to pay attention to its discharge and disposal to avoid polluting water bodies.

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