Synthesis of isothiazolinone

Thiazolidinone is a class of organic compounds containing isothiazole and pyrrole rings, which have a wide range of biological activities and pharmacological applications. The following is a common method for synthesizing isothiazolinone:

The synthesis steps are as follows:

Step 1: Synthesis α- Bromone

Reaction of halogenated carboxylic acids with anhydride to obtain anhydride, and then reaction of anhydride with sulfoxide bromide to generate α- Bromone.

Step 2: Synthesis of isothiazole ring

Using thiourea as raw material, combine it with α- Bromone reacts under alkaline conditions to produce isothiazol alcohol.

Step 3: Pyrrole ring synthesis

React isothiazolinol with aldehydes or ketones and undergo condensation reaction under acidic conditions to produce the target product - isothiazolinone.

It should be noted that the specific method for synthesizing isothiazolinone may vary depending on the experimental conditions, substrate structure, and required products. When conducting chemical synthesis, please ensure that the operating environment is safe, follow relevant safety regulations, and proceed under the guidance of an organic synthesis laboratory or professional.